Numbers following the team names are their latest Perfect Game ranking followed by their RPI.

Teams in blue are predicted winners, teams in orange are predicted second place finishers. Teams that are struck out have been eliminated. Regional winners are listed in bold. Runner-ups are italicized.

Bowling Green, KY

1. Science and Arts (5,10)
2. Campbellsville (18, 11)
3. Reinhardt (NR, 25)
4. Bellevue (NR, 29)
5. Midland (NR, 53)

Hattiesburg, MS

1. St. Thomas (2,3)
2. Westmont (NR, 37)
3. IU Southeast (14, 30)
4. LSU Shreveport (21, 40)
5. William Carey (NR, 23)

Kingsport, TN

1. Southeastern (7,6)
2. Tennessee Wesleyan (16, 7)
3. Madonna (NR, 13)
4. Clarke (NR, 31)
5. Trinity Christian (NR, 90)

Lawrenceville, GA

1. Georgia Gwinnett (4,1)
2. Lyon (22, 16)
3. Keiser (NR, 14)
4. Indiana Wesleyan (NR, 91)
5. Point (NR, 33)

Lincoln, CA

1. William Jessup (11, 34)
2. Middle Georgia State (10, 4)
3. Antelope Valley (9, 35)
4. Judson (NR, 44)
5. British Columbia (NR, 48)

Montgomery, AL

1. Faulkner (1,2)
2. Webber International (25,15)
3. Indiana Tech (24, 21)
4. Talladega (NR, 5)
5. LSU Alexandria (NR, 45)

Oklahoma City, OK

1. Oklahoma City (3,8)
2. Mobile (13, 12)
3. Central Methodist (NR, 36)
4. Jamestown (NR, 32)
5. York (NR, 68)

Upland, IN

1. Oklahoma Wesleyan (6,28)
2. Freed-Hardeman (17, 19)
3. Cumberland (NR, 22)
4. Taylor (23, 57)
5. Northwestern (NR, 60)

Willamsburg, KY

1. Bryan (15, 18)
2. Cumberlands (8, 20)
3. Point Park (12, 45)
4. Univ Northwestern Ohio (NR, 17)
5. Marian (NR, 108)